It all comes down to tail authority. Through testing and experience, Matt has targeted 9500-10500 rpm on the tail rotors. Having variable tail ratios allows the user to fine tune the tail to keep the main rotor head speed in line with pilot needs and yet have enough power at the tail to handle even the most demanding loads.
The stock gear ratio on an E5 is assuming head speeds in the 2300-2500 range with 556 mains and 96mm tails. With a 4.0:1 tail ratio, if the head is turning 2400, then the tail is turning 9600 rpm.
If you stretch the model and turn the head at 2150, on the stock 4.0:1 ratio now the tail is only turning 8600 rpm which is below the ideal range. Increasing tail blades to 106mm increases the amount of force the tail can generate and will help off set some of that.
If you increase the tail ratio to 4.5:1 (12t and 54T spur gears) now at 2150 on the main rotor, the tail is doing 9675 and we are back in the sweet spot for 96mm tails.
Obviously putting larger blades on is the easiest thing and I would certainly start there if you already have the tail blades.
My personal favorite combo for this bird as a 600 class is: 626 mains, 4.5:1 tail, and 106 tails at 2000 rpm. LOVE IT!